Undifferentiated small-cell carcinoma of the urinary bladder: Report of two cases with a primary urinary cytodiagnosis

✍ Scribed by Laura Borghi; Enzo Bianchini; Giuseppe Altavilla

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 673 KB
• Volume: 13
• Category: Article
• ISSN: 8755-1039
• DOI: 10.1002/dc.2840130113

✦ Synopsis

Two undifferentiated small-cell carcinomas of the urinary bladder are reported. The patients, 68-and 55-yr-old men, respectively, presented with painless hematuria. In the first case, numerous small, lymphocyte-like cells with coarse chromatin, sometimes with small nucleoli, and high nuclear/cytoplasmatic ratios were found in cytologic urine specimens. A cytodiugnosis of undifferentiated small-cell cancer was made. In the second case, urine samples showed rare aggregates of small, undirerentiated cells in association with malignant urothelial cells. The cytodiagnosis of mixed tumor composed of undifferentiated small cell and trunsitional carcinoma was conjrmed by histologic examination. The presence of focal reactivity with anti-chromogranin antibody and neurosecretory granules via electron microscopy supports u neuroendocrine differentiation for the small neoplastic cells. The putients died 13 and 8 mo after diagnosis, respectively. Diagn