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Understanding the Role of Active-Site Residues in Chorismate Mutase Catalysis from Molecular-Dynamics Simulations

โœ Scribed by Hong Guo; Qiang Cui; William N. Lipscomb; Martin Karplus


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
210 KB
Volume
42
Category
Article
ISSN
0044-8249

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Understanding the Role of Active-Site Re
โœ Hong Guo; Qiang Cui; William N. Lipscomb; Martin Karplus ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 210 KB ๐Ÿ‘ 1 views

Understanding the role of active-site residues in enzymatic catalysis is of fundamental importance for a microscopic description of the catalytic mechanism, but also for the design of effective enzyme mimics or improvement of existing enzymes (or abzymes) for catalyzing chemical reactions. Site-dire