Understanding the Performance of Biomaterials through Molecular Modeling: Crossing the Bridge between their Intrinsic Properties and the Surface Adsorption of Proteins

✍ Scribed by Giuseppina Raffaini; Fabio Ganazzoli

• Book ID: 102933735
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 814 KB
• Volume: 7
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200600278

✦ Synopsis

Abstract

Molecular modeling and computer simulations can yield significant new insight at the atomistic level about the performance of biomaterials in a biological environment. In this paper, we review our approach to a consistent theoretical picture of the bulk and surface properties of biomaterials. The predicted properties do encompass in particular the mechanical behavior and the surface hydration of these materials, and the surface physisorption of proteins, or polypeptides in general. The behavior of nanomaterials such as the carbon allotropes, nanotubes and fullerenes, in a biological environment is also briefly considered.

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