Understanding the mode of action of ThDP
✍
Kevser Gocmen Topal; Canan Atilgan; Ayhan S. Demir; Viktorya Aviyente
📂
Article
📅
2010
🏛
Wiley (John Wiley & Sons)
🌐
English
⚖ 731 KB
## Abstract The mechanism of all elementary steps involved in the catalytic cycle of benzoylformate decarboxylase (BFD, E.C. 4.1.1.7) to generate the acyloin linkage is investigated by extensive molecular dynamics simulations. Models involving different charge states of amino acids and/or mutants o