## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Understanding the mechanism of sweet taste: Synthesis of tritium labeled guanidineacetic acids
β Scribed by Srinivasan Nagarajan; Michael S. Kellogg; Grant E. Dubois; David S. Williams; Christopher J. Gresk; Charles S. Markos
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 365 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
Syntheses of tritium labeled guanidineacetic acid sweetener and a tritiated photoaffinty labeling reagent via the catalytic hydrogenation of the dibromo intermediates are described. These labeled compounds were required for the investigation of sweet taste mechanism.
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We describe herein the synthesis of polybromodiphenylacetic acid (&), a fragment common to the tritiation substrates (a) and (JJ) of the sodium channel blocker, PD-85639 (1) and the angiotensin II inhibitor EXP-655 (2) respectively. Preparation of (a) and (11) followed by reductive debromonation wit