Understanding the actions of carcinostatic drugs to improve chemotherapy: 5-fluorouracil
β Scribed by H.George Mandel; Philip Klubes; Daniel J. Fernandes
- Book ID
- 118371850
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 716 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0065-2571
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## Background: In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-fu) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. this has enabled them to explore the possibility that the level
## Abstract The metabolic response of the RIFβ1 tumor to 5βfluorouracil (a single dose of 260 mg 5FU/kg, ip) was monitored in 10 mice using ^19^F and ^31^P MR spectroscopy. ^19^F MRS revealed a continuous drop in tumor 5FU level and an increase in the fluoronucleotide (Fnuc) signal to a plateau val