Understanding DNA Damage Response and DNA Repair Pathways: Applications to More Targeted Cancer Therapeutics
β Scribed by Timothy J. Kinsella
- Book ID
- 114474227
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 464 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0093-7754
No coin nor oath required. For personal study only.
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## Abstract Bacteria and eukaryotic cells employ a variety of enzymatic pathways to remove damage from DNA or to lessen its impact upon cellular functions. Most of these processes were discovered in Escherichia coli and have been most extensively analyzed in this organism because suitable mutants h
## Abstract Cigarette smoking is the major risk factor for lung cancer, and together with alcohol for head and neck (Hο£ΏN) cancer. These genotoxics produced DNA damage and particularly doubleβstrand breaks (DSB) that are removed by various repair pathways. To understand the initiation of these cance