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Understanding and modulating apoptosis in industrial cell culture

✍ Scribed by Haley A Laken; Mark W Leonard

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
172 KB
Volume
12
Category
Article
ISSN
0958-1669

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✦ Synopsis

Currently, the production of therapeutic recombinant proteins relies heavily on the large-scale culture of eukaryotic cells that secrete the protein of interest into the media. It has been recognized that programmed cell death, or apoptosis, may pose a significant hurdle to maximum productivity in such systems. With a greater understanding of the molecular events causing apoptosis, alterations can be made to the cells and culture conditions to prevent apoptosis and enhance volumetric productivity.

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