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Underexpressed microRNA-199b-5p targets Hypoxia-Inducible Factor-1α in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients

✍ Scribed by Chuanxi Wang; Bao Song; Wei Song; Jie Liu; Aimin Sun; Dehua Wu; Huiming Yu; Jianping Lian; Longhua Chen; Junqing Han

Book ID
108954166
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
607 KB
Volume
26
Category
Article
ISSN
0815-9319

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## Background: Hypoxia-inducible factor-1 (hif-1) is a transcription factor that plays an important role in tumor growth and metastasis by regulating energy metabolism and inducing angiogenesis to survive cellular hypoxia. increased levels of hif-1alpha, the o(2)-regulated subunit of hif-1, were no