Uncoupling metallonuclease metal ion binding sites via nudge mutagenesis

Mutagenesis studies of the β I domain me

Mutagenesis studies of the β I domain metal ion binding sites on integrin αVβ3 ligand binding affinity

✍ Joel Raborn; Bing-Hao Luo 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 520 KB

## Abstract Three divalent cation binding sites in the integrin β I domain have been shown to regulate ligand binding and adhesion. However, the degree of ligand binding and adhesion varies among integrins. The αLβ2 and α4β7 integrins show an increase in ligand binding affinity and adhesion when on