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Unconventional microbial systems for the cost-efficient production of high-quality protein therapeutics

✍ Scribed by Corchero, José Luis; Gasser, Brigitte; Resina, David; Smith, Wesley; Parrilli, Ermenegilda; Vázquez, Felícitas; Abasolo, Ibane; Giuliani, Maria; Jäntti, Jussi; Ferrer, Pau; Saloheimo, Markku; Mattanovich, Diethard; Schwartz, Simó; Tutino, Maria Luisa; Villaverde, Antonio

Book ID
120224584
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
436 KB
Volume
31
Category
Article
ISSN
0734-9750

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Most proteins for structural biology studies are produced by high-level expression in __Escherichia coli.__ However, prokaryotic based expression systems fail to generate correctly folded functional forms of many proteins and hence a variety of eukaryotic based expression systems have been developed