Unambiguous test for linkage of genes displaying nonallelic interactions for a metrical trait
β Scribed by Jinks, J L
- Book ID
- 109857849
- Publisher
- Nature Publishing Group
- Year
- 1978
- Tongue
- English
- Weight
- 42 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0018-067X
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A more powerful robust test for linkage is developed from the methodology of Haseman and Elston [Behav Genet 2(1):3-19, 19721. This new robust test uses weighted least-squares (WLS) methods to detect linkage between a quantitative trait and a polymorphic marker. For comparison, the characteristics o
## Abstract We present a score for testing association in the presence of linkage for binary traits. The score is robust to varying degrees of linkage, and it is valid under any ascertainment scheme based on trait values as well as under population stratification. The score test is derived from a m