Unaltered cytochrome oxidase, glutamate dehydrogenase and glutaminase activities in platelets from patients with Sporadic Amyotrophic Lateral Sclerosis

Decreased cytochrome c oxidase activity

Decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis

✍ K. Fujita; M. Yamauchi; K. Shibayama; M. Ando; M. Honda; Y. Nagata 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 514 KB

The cause of selective degeneration of motor neurons in the ventral horn of the spinal cord associated with amyotrophic lateral sclerosis (ALS) has still not been elucidated. Recently, so-called oxidative stress has been suggested to be a significant factor in the pathogenesis of this disease. We me