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Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers

✍ Scribed by Graciela Spivak; Toshiki Itoh; Tsukasa Matsunaga; Osamu Nikaido; Philip Hanawalt; Masaru Yamaizumi


Book ID
117798847
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
309 KB
Volume
1
Category
Article
ISSN
1568-7864

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The p53 tumor-suppressor gene has been implicated in the inducible activation of excision repair of ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) in human cells. Because the large T antigen (LTAg) of the simian virus 40 (SV40) binds p53 protein and can interfere with its function, it