Ultraviolet irradiation, tumors, and suppressor T cells
β Scribed by Craig W. Spellman; Raymond A. Daynes
- Book ID
- 119483764
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 351 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1532-8392
No coin nor oath required. For personal study only.
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It was found that sublethal (550 rad) whole-body gamma-irradiation of mice bearing established immunogenic tumors enabled tumor-sensitized spleen cells infused intravenously 1 h later to cause complete tumor regression in all mice. In contrast, gamma-irradiation alone caused only a temporary halt in
## Abstract Splenic irradiation has been employed in tumorβbearing animals to eradicate nonβspecific, spleenβseeking suppressor T cells, and to inhibit established tumor growth. MC1315 tumorβbearing BALB/c mice were treated with 400 R splenic irradiation. Untreated mice or mice receiving 400 R sple
We used in vivo and in vitro assays to determine whether suppressor cells are generated in mice rendered unresponsive to tumor-specific antigens by intravenous (i.v.) injection of non-replicating tumor cells. The results show that a single i.v. injection of 2 X lo7 irradiated P815 tumor cells result