Ultraviolet carcinogenesis

✍ Scribed by Philip Rosen

• Book ID: 104578646
• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 292 KB
• Volume: 9
• Category: Article
• ISSN: 0020-7608
• DOI: 10.1002/qua.560090309

✦ Synopsis

Abstract

A theory of UV carcinogenesis is described in which damage to DNA in the form of pyrimidine dimers occurs in a critical operator region of the genome that controls the synthesis of divisional proteins. There is a chance that a mutation will occur in the region of the operator either during replication or during postreplication repair, so that unchecked growth will be passed on to daughter cells. Comparison with the experiments of Hart and Setlow (1973) indicates that agreement is semiquantitative.