Ultraviolet B radiation downregulates inducible nitric oxide synthase expression induced by interferon-γ or tumor necrosis factor-α in murine keratinocyte Pam 212 cells

Synergistic activation of NF-κb and indu

Synergistic activation of NF-κb and inducible isoform of nitric oxide synthase induction by interferon-γ and tumor necrosis factor-α in INS-1 cells

✍ Nobuo Sekine; Toshio Ishikawa; Tomoki Okazaki; Michio Hayashi; Claes B. Wollheim 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 332 KB 👁 1 views

Interferon-gamma (IFN-gamma) is known to exert deleterious effects on pancreatic beta-cells and is implicated in the development of type 1 (autoimmune) diabetes mellitus. In this study, we investigated signaling mechanisms mediating the effects of IFN-gamma in pancreatic beta-cells using a different