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Ultraviolet B radiation and reactive oxygen species modulate interleukin-31 expression in T lymphocytes, monocytes and dendritic cells

✍ Scribed by C. Cornelissen; R. Brans; K. Czaja; C. Skazik; Y. Marquardt; G. Zwadlo-Klarwasser; A. Kim; D.R. Bickers; J. Lüscher-Firzlaff; B. Lüscher; J.M. Baron

Book ID: 108671879
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 380 KB
Volume: 165
Category: Article
ISSN: 0007-0963
DOI: 10.1111/j.1365-2133.2011.10487.x

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## Abstract Indoleamine 2,3‐dioxygenase (IDO) is the rate‐limiting enzyme in the kynurenine (Kyn) pathway of tryptophan (Trp) metabolism. IDO is immunosuppressive and is induced by inflammation in macrophages and dendritic cells (DCs). Previous studies have shown the serum Kyn/Trp levels in patient