Ultrastructure of the readily soluble paired helical filaments (PHF I) and non-PHF abnormally phosphorylated tau (Ad P Tau)

Monoclonal antibody PHF-9 recognizes pho

Monoclonal antibody PHF-9 recognizes phosphorylated serine 404 of tau protein and labels paired helical filaments

✍ Frank P. Zemlan; Gary E. Dean 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 775 KB

Paired helical filaments (PHFs) purified from Alzheimer's brain consist of hyperphosphorylated microtubule-associated protein tau. In PHF, phosphorylation occurs at ser/thr tau residues. Several of these ser/thr phosphorylation sites lie immediately C-terminal to the tau tubulin binding domain. The