Ultrastructure of the interface between alumina bead composite and bone

✍ Scribed by Okada, Yoshifumi ;Kobayashi, Masahiko ;Neo, Masashi ;Shinzato, Shuichi ;Matsushita, Mutsumi ;Kokubo, Tadashi ;Nakamura, Takashi

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 434 KB
• Volume: 49
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(200001)49:1<106::aid-jbm13>3.0.co;2-w

✦ Synopsis

We developed a composite (ABC) consisting of alumina bead powder as an inorganic filler and bisphenola-glycidyl dimethacrylate (Bis-GMA)-based resin as an organic matrix. Alumina bead powder was manufactured by fusing crushed ␣-alumina powder and quenching it. The beads took a spherical form 3 m in average diameter. The proportion of filler in the composites was 70% w/w. The composite was implanted into rat tibiae and cured in situ. Specimens were prepared 1, 2, 4, and 8 weeks after the operation and observed by transmission electron microscopy. The results were compared with those of a bone composite made of ␣-alumina powder (␣-ALC). In ABC-implanted tibiae, the uncured surface layer of Bis-GMA-based resin was completely filled with newly formed bonelike tissue 2 weeks after implantation. The alumina bead fillers were surrounded by and in contact with bonelike tissue. No intervening soft tissue was seen. In ␣-ALC-implanted tibiae, a gap was always observed between the ␣-ALC and the bonelike tissue. These results indicate that the ABC has osteoconductivity, although the precise mechanism is still unclear.