✦ LIBER ✦

Ultrastructure of the fragile X chromosome: New observations on the fragile site

✍ Scribed by Wen, Guang Y.; Jenkins, Edmund C.; Goldberg, Erick M.; Genovese, Marilyn; Brown, W. Ted; Wisniewski, Henryk M.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 24 KB
Volume: 83
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19990402)83:4<331::aid-ajmg21>3.0.co;2-u

No coin nor oath required. For personal study only.

✦ Synopsis

Using a nonair-drying modification of a method for longitudinal sectioning of metaphase spreads on glass slides [Wen et al., 1997], we have studied 14 preidentified X chromosomes (10 from fragile X specimens and 4 controls) with transmission electron microscopy (TEM). Four of 10 X chromosomes from fragile X specimens exhibited lighter chromatin density in the area of and distal to the fragile site, most pronounced under dark-field TEM. A clear line of separation at the fragile site locus was also observed by TEM in an X chromosome with no visible fragile site after Q-banding. We hypothesize that these areas of lighter density, including lines of separation, precede the appearance of the fragile site that is commonly observed using light microscopy. Am.

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