Ultrastructural localization of the binding sites of antibasement membrane zone antibodies in lichen planus pemphigoides on 1.0Msodium chloride-separated skin
✍ Scribed by S. Ikeda; Y. Song; H. Yaguchi; K. Naito; S. Morioka; H. Ogawa; T. Muramatsu
- Publisher
- Springer-Verlag
- Year
- 1989
- Tongue
- English
- Weight
- 278 KB
- Volume
- 281
- Category
- Article
- ISSN
- 0340-3696
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✦ Synopsis
Lichen planus pemphigoides -Anti-basement membrane zone antibodies -In vitro binding sites Lichen planus pemphigoides (LPP) has been defined and characterized by its clinical, pathological, and immunohistochemical features consistent with both lichen planus (LP) and bullous pemphigoid (BP) [2, 3, 5, 8-10, 12, 13]. Several authors [2,5,8,10,12,13], regard LPP as being coexistent with LP and BP, however, there has also been continuous discussion concerning the nosological position of LPP. In studies on LPP antigen, Lang and Maize [3] and Prost et al. [9] indicated that the LPP antigen differs from BP antigen, on the basis of experimental results by immunoprecipitation of cultured human keratinocytes with patient's serum, or direct immunoelectron microscopy of patient's skin; they also suggested that LPP possesses a new clinical entity distinct from BP. On the other hand, Okada et al. [7] indicated that antibodies of BP sera and of drug-induced LPP identified the same 240 kD antigen synthesized by SV 40-transformed keratinocytes, thereby supporting the hypothesis that LPP does coexist with LP and BP.
The purpose of this study was to investigate the binding sites of LPP antibodies in vitro and then try to determine the properties of LPP antigen, since indirect immunoelectron microscopy has previously not been carried out.