𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Ultrastructural localization of CART (cocaine- and amphetamine-regulated transcript) peptides in the nucleus accumbens of monkeys

✍ Scribed by Yoland Smith; Ersin O. Koylu; Pastor Couceyro; Michael J. Kuhar

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
359 KB
Volume
27
Category
Article
ISSN
0887-4476

No coin nor oath required. For personal study only.

✦ Synopsis

CART (cocaine-and amphetamine-regulated transcript)

peptides are proposed to play a role in the action of psychostimulants as neurotransmitters/ neuromodulators. In the present study, we demonstrate that the shell of the nucleus accumbens, a brain structure involved in drug reinforcement, is densely innervated by a dense plexus of CART peptide-immunoreactive varicose fibers in register with immunoreactive perikarya in monkeys. At the electron microscopic level, varicosities appeared as immunoreactive axon terminals packed with round electron-lucent vesicles and a variable number of darkly stained dense-core vesicles that formed symmetric synapses with dendrites. These findings suggest that CART peptides may be a cotransmitter with gamma aminobutyric acid (GABA) in intrinsic axon collaterals of striatal projection neurons or interneurons in the primate nucleus accumbens.

πŸ“œ SIMILAR VOLUMES

Cocaine- and amphetamine-regulated trans
Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in myenteric plexus neurons of the rat ileum and co-localization with choline acetyltransferase
✍ Pastor Couceyro; Maryse Paquet; Ersin Koylu; Michael J. Kuhar; Yoland Smith πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 333 KB πŸ‘ 2 views

Cocaine and amphetamine regulated transcript (CART) encodes a novel brain-enriched protein whose features are reminiscent of a neurotransmitter propeptide. We have now localized CART peptide(s) in the gastrointestinal tract by immunohistochemical methods. Polyclonal antisera raised to CART peptide 1

CART peptide-immunoreactive neurones in
CART peptide-immunoreactive neurones in the nucleus accumbens in monkeys: Ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents
✍ Smith, Y.; Kieval, J.; Couceyro, P.R.; Kuhar, M.J. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 782 KB

Cocaine-and amphetamine-regulated transcript (CART) is a novel mRNA whose level of expression was found to be increased in the striatum after acute administration of psychomotor stimulants in rats. To define better the potential role of CART peptides in behavioural and physiologic changes induced by