Cerebral vascular accumulation of Dutch-
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Kazuchika Nishitsuji; Takami Tomiyama; Kenichi Ishibashi; Fuyuki Kametani; Kazuh
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Article
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2007
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John Wiley and Sons
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English
⚖ 284 KB
## Abstract Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA‐D), is an autosomal dominant disorder caused by the Dutch mutation (E693Q) in the β‐amyloid precursor protein. This mutation produces an aberrant amyloid β (Aβ) species (AβE22Q) and causes severe meningocortical vascular