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Ultrastructural evidence of early non-fibrillar Aβ42 in the capillary basement membrane of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type

✍ Scribed by R. Natté; Haruyasu Yamaguchi; Marion L. C. Maat-Schieman; Frans A. Prins; Peter Neeskens; Raymund A. C. Roos; Sjoerd G. van Duinen


Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
726 KB
Volume
98
Category
Article
ISSN
0001-6322

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Cerebral vascular accumulation of Dutch-
✍ Kazuchika Nishitsuji; Takami Tomiyama; Kenichi Ishibashi; Fuyuki Kametani; Kazuh 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB

## Abstract Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA‐D), is an autosomal dominant disorder caused by the Dutch mutation (E693Q) in the β‐amyloid precursor protein. This mutation produces an aberrant amyloid β (Aβ) species (AβE22Q) and causes severe meningocortical vascular