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Ultrastructural comparison of hydroxyapatite and silicon-substituted hydroxyapatite for biomedical applications

✍ Scribed by Porter, Alexandra E. ;Best, Serena M. ;Bonfield, William

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
422 KB
Volume
68A
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

Silicon‐substituted hydroxyapatite (Si‐HA) has been shown to lead to significantly increased rates of bone apposition when compared with phase‐pure hydroxyapatite (HA) bioceramic implants (Patel N, et al. J Mater Sci Mater Med 2002;13:1199–1206). However, uncertainty remains about the mechanism by which Si increases the in vivo bioactivity. In this study, defect structures in Si‐HA were observed and characterized for the first time using high‐resolution transmission electron microscopy. Using tilting experiments and the g · b = 0 criterion for invisibility, the Burgers vectors of dislocations in phase‐pure HA and 0.8 wt % Si‐HA were characterized to be screw and mixed in character. Dislocations were observed in both pure HA and 0.8 wt % Si‐HA with no significant difference in dislocation density between HA and Si‐HA. However, our findings suggest that an increased number of triple junctions in Si‐HA may have a significant role in increasing the solubility of the material and the subsequent rate at which bone apposes Si‐HA ceramics. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 133–141, 2004

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