Ultrastructural and cytochemical changes in tissue culture infected with type 5 adenovirus

Adenovirus type 5 uptake by lung adenoca

Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad5 fibre binding is mediated by αvβ1 integrin and can be modulated by changes in β1 integrin function

✍ Elizabeth Davison; Ian Kirby; Joanna Whitehouse; Ian Hart; John F. Marshall; Geo 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB

Background Recombinant adenoviruses (Ad) have been employed as vectors for a wide variety of gene therapy applications, but their use has been hindered by problems relating to efficacy and safety. The efficiency of Ad-mediated gene transfer depends on the interaction of the fibre and penton base pro