Ultrasound-promoted greener approach to synthesize α-hydroxy phosphonates catalyzed by potassium dihydrogen phosphate under solvent-free condition

✍ Scribed by Priyanka G. Mandhane; Ratnadeep S. Joshi; Deepak R. Nagargoje; Charansingh H. Gill

• Book ID: 104097367
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 246 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.01.031

✦ Synopsis

We report a new environmentally-benign, convenient, and facile methodology for the synthesis of ahydroxyphosphonates from an aromatic/heteroaromatic aldehyde with triethyl phosphite in the presence of potassium dihydrogen phosphate (KH 2 PO 4 ) under ultrasound-assisted solvent-free conditions. Furthermore, a series of compounds were synthesized and characterized by melting point, EI-MS, NMR, and IR tools. Utilization of easy reaction conditions, isolation, and purification makes this manipulation very interesting from an economic perspective.