Drug resistance has been associated with resistance to NKand LAK-cell-mediated cytotoxicity. We evaluated this issue in human cell lines, using multiple myeloma cells (8226) and 2 multi-drug-resistant (MDR) sublines selected using doxorubicin (8226/Dox40) and mitoxantrone (8226lMR40). In parallel, w
β¦ LIBER β¦
Ultrasound-Induced Hyperthermia Increases Cellular Uptake and Cytotoxicity of P-Glycoprotein Substrates in Multi-Drug Resistant Cells
β Scribed by Yang Liu; Cheong-Weon Cho; Xiangdong Yan; Thomas K. Henthorn; Kevin O. Lillehei; Wesley N. Cobb; Ka-yun Ng
- Book ID
- 110318367
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 518 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0724-8741
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## Abstract Because solid growing tumors often show hypoxia and pronounced extracellular acidosis, the aim of this study was to analyze the impact of an acidotic environment on the activity of the pβglycoprotein (pGP) and on the cellular content and cytotoxicity of the chemotherapeutic drug daunoru