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Ultracentrifuge Studies of Red Cell Phosphoglucomutase

✍ Scribed by SANTACHIARA, A. SILVANA BENERECETTI; MODIANO, GUIDO


Book ID
109668690
Publisher
Nature Publishing Group
Year
1969
Tongue
English
Weight
294 KB
Volume
223
Category
Article
ISSN
0028-0836

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A total of 637 individuals from the rural village of Keneba in The Gambia, West Africa, have been typed for red cell PGM using isoelectric focusing (pH 5--7) in polyacrylamide gels. Eight different phenotypes have been detected. The frequency of the four alleles at the PGM1 locus was found to be PGM

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Reduced phosphoglucomutase (PGM) activity (approximately 25% of normal) was found in erythrocytes from a healthy newborn infant. The PGM activity was also diminished (approximately 50% of normal) in the erythrocytes of the parents. No PGM1 isoenzymes were found in the erythrocytes of the propositus,