Ultra scale-down approaches for clarification of mammalian cell culture broths in disc-stack centrifuges

Ultra scale-down prediction using microw

Ultra scale-down prediction using microwell technology of the industrial scale clarification characteristics by centrifugation of mammalian cell broths

✍ A.S. Tait; J.P. Aucamp; A. Bugeon; M. Hoare 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB

## Abstract This article describes how a combination of an ultra scale‐down (USD) shear device feeding a microwell centrifugation plate may be used to provide a prediction of how mammalian cell broth will clarify at scale. In particular a method is described that is inherently adaptable to a roboti