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Ultra-performance liquid chromatography–tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic study

✍ Scribed by Jing Tang; Ronghua Zhu; Ruike Zhao; Gang Cheng; Wenxing Peng

Book ID: 108189534
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 547 KB
Volume: 47
Category: Article
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2008.04.018

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## Abstract A rapid and sensitive LC/MS/MS assay was developed and validated for the determination of clopidogrel in human plasma. Clopidogrel was extracted by single liquid–liquid extraction with pentane, and chromatographic separations were achieved on a C~18~ column. The method was validated to