Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy

Effect of intrapatient dosage escalation

Effect of intrapatient dosage escalation of irinotecan on its pharmacokinetics in pediatric patients who have high-grade gliomas and receive enzyme-inducing anticonvulsant therapy

✍ Amar Gajjar; Murali M. Chintagumpala; Daniel C. Bowers; Dana Jones-Wallace; Clin 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB

The authors set out to determine the effect of intrapatient dose escalation of irinotecan on its disposition in pediatric patients with high-grade glioma who received concomitant enzyme-inducing anticonvulsants (EIAs). During Course 1, a 60-minute intravenous infusion of irinotecan (20 mg/m(2) per d