UL97 sequence variation of multiple post mortem tissues from AIDS patients following ganciclovir therapy

Quantitative differences in the distribu

Quantitative differences in the distribution of zidovudine resistance mutations in multiple post-mortem tissues from AIDS patients

✍ Atkins, Mark; Strappe, Padraig; Kaye, Steve; Loveday, Clive; McLaughlin, James E 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 302 KB 👁 3 views

Replication of HIV introduces errors into the genome which are responsible for conferring a growth advantage over wildtype virus when drugs such as zidovudine (ZDV) exert a selective pressure. The molecular basis for HIV-1 resistance to ZDV has been mapped to codons 41, 67, 70, 215 and 219 of the re