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UHRF1 inhibitsMDR1gene transcription and sensitizes breast cancer cells to anticancer drugs

✍ Scribed by Wei Jin; Yang Liu; Si-guang Xu; Wen-jin Yin; Jun-jie Li; Jin-ming Yang; Zhi-ming Shao

Book ID
106378535
Publisher
Springer US
Year
2009
Tongue
English
Weight
460 KB
Volume
124
Category
Article
ISSN
0167-6806

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## Abstract The Runx3 gene is a member of the runt domain family transcription factors, key regulators of development and differentiation in metazoan. Recently, Runx3 was identified as a tumor suppressor gene. Loss of Runx3 was found to be associated with genesis and progression of gastric cancer.