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UGT1A1*6 polymorphisms are correlated with irinotecan-induced toxicity: a system review and meta-analysis in Asians

✍ Scribed by Cheng, Lei; Li, Ming; Hu, Jing; Ren, Wei; Xie, Li; Sun, Zhan-Peng; Liu, Bao-Rui; Xu, Gen-Xing; Dong, Xiao-Liang; Qian, Xiao-Ping


Book ID
121544944
Publisher
Springer
Year
2014
Tongue
English
Weight
819 KB
Volume
73
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th