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Ugi four-component condensation with two cleavable components: the easiest synthesis of 2,N-diarylglycines

✍ Scribed by Cristina Faggi; Ana G. Neo; Stefano Marcaccini; Gloria Menchi; Julia Revuelta

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 177 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.01.134

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✦ Synopsis

The Ugi four-component condensation between anilines, aromatic aldehydes, isocyanides, and a-oxoacids afforded the expected adducts which were cleaved in mild conditions to give 2,N-diarylglycines in high yields.

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