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UFT for head and neck cancers: its tissue concentrations and effects on lymphocyte subpopulations

✍ Scribed by Masayoshi Tachibana; Norio Yasuda; Masaki Yoshimatsu; Hideo Nishimura; Osamu Mizukoshi

Book ID: 104710235
Publisher: Springer
Year: 1987
Tongue: English
Weight: 310 KB
Volume: 19
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00296259

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✦ Synopsis

UFT, a combination of the masked compound of 5-fluorouracil (FT-207) and uracil, was given to head and neck cancer patients for 1 week preoperatively and for 8 weeks postoperatively. Drug concentrations were examined in the surgically removed tissues. The concentrations of FT-207, 5-fluorouracil, and uracil were higher in tumor tissues than in normal tissues. The lymphocyte subpopulations were assessed by cytofluorometry with monoclonal antibodies. There was no evidence that adjuvant chemotherapy with UFT specifically suppresses immunocompetent cells. We therefore conclude that further clinical evaluation of adjuvant chemotherapy with UFT would be worthwhile.

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