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UCN-01 alters phosphorylation of Akt and GSK3β and induces apoptosis in six independent human neuroblastoma cell lines

✍ Scribed by Sai Latha Shankar; Melissa Krupski; Bhupesh Parashar; Chidi Okwuaka; Kathy O'Guin; Sridhar Mani; Bridget Shafit-Zagardo


Book ID
110103411
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
359 KB
Volume
90
Category
Article
ISSN
0022-3042

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## Abstract Exogenous β~2~‐microglobulin (β~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. β~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF