UCHL1-positive extranodal lymphoma resembling multiple lymphomatous polyposis of the gastrointestinal tract

✍ Scribed by Hirokazu Nakamine; Haruhiko Sakamoto; Tomoyuki Tanaka; Nobukazu Nakashima; Toru Takenaka; Jiro Maeda

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 560 KB
• Volume: 64
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19891001)64:7<1500::aid-cncr2820640723>3.0.co;2-o

✦ Synopsis

Histopathologic and immunohistochemical studies were done on paraffin sections from a patient with alimentary tract lymphoma resembling multiple lymphomatous polyposis of the gastrointestinal tract (MLP). Diffuse, but not follicular, proliferation of medium-sized lymphoid cells was noted in the polypoid lesions of the alimentary tract, peripancreatic lymph nodes, spleen, liver, and hone marrow. These cells possessed a T-cell-related antigen (UCHLl), but were negative for the B-cell-related and myeloid cellrelated antigens examined. Because neoplastic cells in MLP are usually of B-cell origin, the current case will provide important information on the relation between phenotypes and morphologic patterns of proliferation.