Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenase

Reversal of inflammation-associated dihy

Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin

✍ Hao-Wei Wang; Chin-Ping Lin; Jen-Hwey Chiu; Kuan-Chih Chow; Kuang-Tai Kuo; Chen- 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 451 KB

## Abstract Dihydrodiol dehydrogenase (DDH) is a member of the aldo‐keto reductases superfamily (AKR1C1–AKR1C4), which plays central roles in the metabolism of steroid hormone, prostaglandin and xenobiotics. We have previously detected overexpression of DDH as an indicator of poor prognosis and che