Ubiquitins Revisited: Further Examples of Within- and Between-Locus Concerted Evolution
✍ Scribed by Ying Tan; Stephen T. Bishoff; Margaret A. Riley
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 686 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1055-7903
No coin nor oath required. For personal study only.
✦ Synopsis
Ubiquitin genes provide a model for studying the effects of concerted evolution on the evolution of a family of short repeated sequences. Previous work has demonstrated the occurrence of within-locus concerted evolution and raised the question of the effectiveness of between-locus concerted evolution for ubiquitin repeats. In this study comparative analysis of additional nucleotide sequences of ubiquitin tandem repeats provides further details of within-locus concerted evolution. Moreover, the availability of multiple polyubiquitin loci and ubiquitin fusion loci within a species makes possible the detection of between-locus concerted evolution. These data indicate that concerted evolution is an effective force for homogenizing repeats between, as well as within, loci.