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Ubiquitin-proteasome inhibition enhances apoptosis of human pancreatic cancer cells

✍ Scribed by Theodore P. McDade; Richard A. Perugini; Frank J. Vittimberga Jr; Mark P. Callery

Book ID
117221334
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
178 KB
Volume
126
Category
Article
ISSN
0039-6060

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## Abstract The 26S proteasome degrades proteins that regulate transcription factor activation, cell cycle progression, and apoptosis. In cancer, this may allow for uncontrolled cell division, promoting tumor growth, and spread. We examined whether selective inhibition of the 26S proteasome with PS