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Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators

✍ Scribed by P. Renee Yew


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
163 KB
Volume
187
Category
Article
ISSN
0021-9541

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We previously reported that all-trans retinoic acid (RA) and fenretinide (4HPR) suppress HL-60 leukemia cell growth and cause partial cell arrest in the G 1 -to-S phase. Moreover, 4HPR but not RA induces apoptosis in HL-60 cells. To investigate further the observed biological effects, cyclin D1 and