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Ubiquitin-Mediated Degradative Pathway Degrades the Extracellular but Not the Intracellular Form of Amyloid β-Protein Precursor

✍ Scribed by L. Gregori; R. Bhasin; D. Goldgaber

Book ID: 115575412
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 488 KB
Volume: 203
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1994.2386

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas