On ubiquitin ligases and cancer
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Jacques S. Beckmann; Fabienne Maurer; Mauro Delorenzi; Laurent Falquet
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Article
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2005
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John Wiley and Sons
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English
β 125 KB
Protein kinase genes account for almost 10% of all currently known cancer genes, highlighting the role of signal transduction in oncogenesis. A reexamination of the literature and available databases shows that E3 ubiquitin ligases are also key mediators of tumorigenesis. Altogether kinase and E3 ge