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Ubiquitin ligase WWP1 inhibits mesenchymal stem cell differentiation into osteoblasts by inducing degradation of JunB

✍ Scribed by L. Xing; H. Zhang; L. Shu; L. Zhao; D. Chen; B. Boyce

Book ID
116324216
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
51 KB
Volume
48
Category
Article
ISSN
8756-3282

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Ubiquitin ligase Smurf1-deficient mice develop an increased-bone-mass phenotype in an age-dependent manner. It was reported that such a bone-mass increase is related to enhanced activities of differentiated osteoblasts. Although osteoblasts are of mesenchymal stem cell (MSC) origin and MSC prolifera