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Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target

✍ Scribed by Nitzan Shabek; Kazuhiro Iwai; Aaron Ciechanover


Book ID
116295643
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
487 KB
Volume
363
Category
Article
ISSN
0006-291X

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The ubiquitin/proteasome pathway is a highly conserved mechanism of proteolysis in all eukaryotes. Ubiquitin (Ub) is conjugated to proteolytic substrates through the sequential action of ubiquitin-activating (E1/Uba) and ubiquitin-conjugating (E2/Ubc) enzymes. The mechanism of substrate recognition