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Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes

✍ Scribed by Robert C Piper; J Paul Luzio

Book ID
113524897
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
383 KB
Volume
19
Category
Article
ISSN
0955-0674

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The protein composition of the integral lysosomal membrane and the membrane-associated compartment have been defined in part by proteomics approaches. While the role of its constituent hydrolases in a large array of human disorders has been well-documented, the manner in which membrane proteins are