Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats
β Scribed by Ming C. Liu; Linnet Akinyi; Dancia Scharf; Jixiang Mo; Stephen F. Larner; Uwe Muller; Monika W. Oli; Wenrong Zheng; Firas Kobeissy; Linda Papa; Xi-Chun Lu; Jitendra R. Dave; Frank C. Tortella; Ronald L. Hayes; Kevin K. W. Wang
- Book ID
- 109028121
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 744 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0953-816X
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## Abstract By using two different approaches, ubiquitin Cβterminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage and disease states. Appropriate antibodies and a se
## Abstract Traumatic brain injury (TBI) occurs suddenly and has damaging effects to the brain that are dependent on the severity of insult. Symptoms can be mild, moderate, or severe. Oxidative damage is associated with traumatic brain injury through reactive oxygen/nitrogen species production. One