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U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells

✍ Scribed by Agnes Tatrai; Kyeong Lee Suk; Paula H. Stern

Book ID
116106215
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
655 KB
Volume
1224
Category
Article
ISSN
0167-4889

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## Abstract 1,25‐Dihydroxyvitamin D~3~ (1,25(OH)~2~D~3~) treatment of osteoblastic cells was shown previously to attenuate Parathyroid hormone (PTH) response by inhibiting adenylyl cyclase (AC) activity. In this study, we have investigated the mechanism by which 1,25(OH)~2~D~3~ inhibits AC in rat o